High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

Abstract Diabetes (DB) is a risk factor for osteoarthritis progression. High glucose (HG) is one of the key pathological features of DB and has been demonstrated to induce apoptosis and senescence in chondrocytes. Autophagy is an endogenous mechanism that can protect cells against apoptosis and sene...

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Bibliographic Details
Main Authors: Ben Wang, Yifeng Shi, Jiaoxiang Chen, Zhenxuan Shao, Libin Ni, Yan Lin, Yaosen Wu, Naifeng Tian, Yifei Zhou, Liaojun Sun, Aimin Wu, Zhenghua Hong, Xiangyang Wang, Xiaolei Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03791-9

Internet

https://doi.org/10.1038/s41419-021-03791-9

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