Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

Resolution-phase macrophage population orchestrates active dampening of the inflammation by secreting anti-inflammatory and proresolving products including interleukin (IL)-10 and lipid mediators (LMs). We investigated the effects of both human bone marrow-derived mesenchymal stromal cells (MSCs) an...

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Bibliographic Details
Main Authors: Kati Hyvärinen, Minna Holopainen, Vita Skirdenko, Hanna Ruhanen, Petri Lehenkari, Matti Korhonen, Reijo Käkelä, Saara Laitinen, Erja Kerkelä
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
regulatory macrophages
mesenchymal stromal cells
extracellular vesicles
interleukin-23
prostaglandin E2
resolution
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00771/full

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http://journal.frontiersin.org/article/10.3389/fimmu.2018.00771/full

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