Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin

Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin

Resistance to cisplatin (CDDP) is a major cause of cancer treatment failure, including human breast cancer. The tumor suppressor protein p53 is a key factor in the induction of cell cycle arrest, DNA repair, and apoptosis in response to cellular stimuli. This protein is phosphorylated in serine 15 a...

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Bibliographic Details
Main Authors: Jorge Hernandez-Valencia, Enrique Garcia-Villa, Aquetzalli Arenas-Hernandez, Jaime Garcia-Mena, Jose Diaz-Chavez, Patricio Gariglio
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Nutrients
Subjects:
breast cancer
cisplatin
p53
phosphorylation
resistance
resveratrol
Online Access:http://www.mdpi.com/2072-6643/10/9/1148

Internet

http://www.mdpi.com/2072-6643/10/9/1148

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