Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells

Crystal structure of a cytocidal protein from lamprey and its mechanism of action in the selective killing of cancer cells

Abstract Background In previous research, we found that lamprey immune protein (LIP) possessed cytocidal activity against tumor cells, but the mechanism of the selective recognition and killing of tumor cells by LIP was not identified. Methods Superresolution microscopy, crystallographic structural...

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Bibliographic Details
Main Authors: Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang, Qingwei Li
Format: Article
Language:English
Published: BMC 2019-05-01
Series:Cell Communication and Signaling
Subjects:
Lamprey
LIP
Cytotoxic activity
Selective recognition
GPI-APs
Online Access:http://link.springer.com/article/10.1186/s12964-019-0358-y

Internet

http://link.springer.com/article/10.1186/s12964-019-0358-y

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