Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Hydroxychloroquine Induces Apoptosis in Cholangiocarcinoma via Reactive Oxygen Species Accumulation Induced by Autophagy Inhibition

Purpose: Despite considerable efforts to improve treatment modalities for cholangiocarcinoma, a common form of malignant tumor, its long-term survival rate remains poor. Hydroxychloroquine (HCQ) is a 4-aminoquinoline derivative antimalarial drug that has antimalarial and autophagy inhibition effects...

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Bibliographic Details
Main Authors: Jiaqi Chen, Qiaoya Pan, Yang Bai, Xuepeng Chen, Yi Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
HCQ
cholangiocarcinoma
ROS
autophagy
TCGA
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.720370/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.720370/full

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