CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

Innate immune signaling relies on the deposition of non-degradative polyubiquitin at receptor-signaling complexes, but how these ubiquitin modifications are regulated by deubiquitinases remains incompletely understood. Met1-linked ubiquitin (Met1-Ub) is assembled by the linear ubiquitin assembly com...

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Bibliographic Details
Main Authors: Matous Hrdinka, Berthe Katrine Fiil, Mattia Zucca, Derek Leske, Katrin Bagola, Monica Yabal, Paul R. Elliott, Rune Busk Damgaard, David Komander, Philipp J. Jost, Mads Gyrd-Hansen
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716301838

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http://www.sciencedirect.com/science/article/pii/S2211124716301838

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