Inhibition of the IGF-1–PI3K–Akt–mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis

Inhibition of the IGF-1–PI3K–Akt–mTORC2 pathway in lipid rafts increases neuronal vulnerability in a genetic lysosomal glycosphingolipidosis

Glycosphingolipid (GSL) accumulation is implicated in the neuropathology of several lysosomal conditions, such as Krabbe disease, and may also contribute to neuronal and glial dysfunction in adult-onset conditions such as Parkinson's disease, Alzheimer's disease and multiple sclerosis. GSL...

Full description

Bibliographic Details
Main Authors: Tuba Sural-Fehr, Harinder Singh, Ludovico Cantuti-Catelvetri, Hongling Zhu, Michael S. Marshall, Rima Rebiai, Martin J. Jastrzebski, Maria I. Givogri, Mark M. Rasenick, Ernesto R. Bongarzone
Format: Article
Language:English
Published: The Company of Biologists 2019-05-01
Series:Disease Models & Mechanisms
Subjects:
IGF-1
Neurodegeneration
Krabbe disease
Sphingolipid
Akt
mTOR
Membrane dysfunction
Neuroprotection
Lipid raft
Phosphorylation
GSK3β
Online Access:http://dmm.biologists.org/content/12/5/dmm036590

Internet

http://dmm.biologists.org/content/12/5/dmm036590

Similar Items