Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice

Lentiviral vector-mediated rescue of motor behavior in spontaneously occurring hereditary ataxic mice

Hotfoot5J mice are spontaneously occurring ataxic mice that lack δ2 glutamate receptor (GluRδ2) protein in cerebellar Purkinje cells. Here we aimed to rescue the ataxic phenotype of hotfoot5J mice by lentiviral vector-mediated expression of recombinant GluRδ2 in Purkinje cells. Lentiviral vectors ex...

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Bibliographic Details
Main Authors: Akira Iizuka, Kiyohiko Takayama, Takashi Torashima, Miwako Yamasaki, Chiho Koyama, Kazuhiro Mitsumura, Masahiko Watanabe, Hirozaku Hirai
Format: Article
Language:English
Published: Elsevier 2009-09-01
Series:Neurobiology of Disease
Subjects:
Lentivirus
Viral vector
Purkinje cell
Cerebellum
Delta2
Glutamate receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001442

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http://www.sciencedirect.com/science/article/pii/S0969996109001442

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