Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro

Melatonin Prevents Mice Cortical Astrocytes From Hemin-Induced Toxicity Through Activating PKCα/Nrf2/HO-1 Signaling in vitro

Secondary injuries mediated by oxidative stress lead to deterioration of neurological functions after intracerebral hemorrhage (ICH). Cortical astrocytes are among the most important cells in the central nervous system (CNS), and play key roles in maintaining redox homeostasis by providing oxidative...

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Bibliographic Details
Main Authors: Xiao Chen, Zhiyu Xi, Huaibin Liang, Yuhao Sun, Zhihong Zhong, Baofeng Wang, Liuguan Bian, Qingfang Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Neuroscience
Subjects:
intracerebral hemorrhage
hemin
melatonin
PKCα
Nrf2
oxidative stress
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00760/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2019.00760/full

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