Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice

Hematopoietic or Osteoclast-Specific Deletion of Syk Leads to Increased Bone Mass in Experimental Mice

Syk is a non-receptor tyrosine kinase critically involved in signaling by various immunoreceptors including B-cell-receptors and activating Fc-receptors. We have previously shown that Syk also mediates immunoreceptor-like signals required for the in vitro development and function of osteoclasts. How...

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Bibliographic Details
Main Authors: Dániel Csete, Edina Simon, Ahmad Alatshan, Petra Aradi, Csaba Dobó-Nagy, Zoltán Jakus, Szilvia Benkő, Dávid S. Győri, Attila Mócsai
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
SYK (spleen tyrosine kinase)
tyrosine kinase
osteoclasts
Cre-Lox
in vivo
mice
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00937/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00937/full

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