Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet

Abstract Background Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide, although its pathogenesis remains to be elucidated. A recent study revealed that hepatic Niemann-Pick C1-Like 1 (NPC1L1), a cholesterol re-absorber from bile to the liver expressed on th...

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Bibliographic Details
Main Authors: Yu Toyoda, Tappei Takada, Yoshihide Yamanashi, Hiroshi Suzuki
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Lipids in Health and Disease
Subjects:
Cholesterol transporter
Ezetimibe
Hepatic stress
Lipotoxicity
Reabsorption of biliary secreted cholesterol
Steatosis model animal
Online Access:https://doi.org/10.1186/s12944-019-1179-0

Internet

https://doi.org/10.1186/s12944-019-1179-0

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