Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma

Background and AimsMammalian target of rapamycin complex 1 (mTORC1) is frequently hyperactivated in hepatocellular carcinoma (HCC). Cases of HCC without inflammation and cirrhosis are not rarely seen in clinics. However, the molecular basis of non-inflammatory HCC remains unclear.MethodsSpontaneous...

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Bibliographic Details
Main Authors: Ting Li, Guohong Zhang, Linlin Wang, Susu Li, Xiaoping Xu, Yi Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
carcinogenesis
mouse model
non-inflammation
gene network
metabolic disorder
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00225/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2020.00225/full

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