Group A Streptococcus Induces LAPosomes via SLO/β1 Integrin/NOX2/ROS Pathway in Endothelial Cells That Are Ineffective in Bacterial Killing and Suppress Xenophagy
Our previous reports showed that the LC3-associated GAS-containing single membrane vacuoles are inefficient for bacterial clearance in endothelial cells, which may result in bacteremia. However, the characteristics and the induction mechanisms of these LC3-positive vacuoles are still largely unknown...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2019-10-01
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Series: | mBio |
Subjects: | |
Online Access: | https://doi.org/10.1128/mBio.02148-19 |