Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

Molecular pathway profiling of T lymphocyte signal transduction pathways; Th1 and Th2 genomic fingerprints are defined by TCR and CD28-mediated signaling

<p>Abstract</p> <p>Background</p> <p>T lymphocytes are orchestrators of adaptive immunity. Naïve T cells may differentiate into Th1, Th2, Th17 or iTreg phenotypes, depending on environmental co-stimulatory signals. To identify genes and pathways involved in differentiat...

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Bibliographic Details
Main Authors: Smeets Ruben L, Fleuren Wilco WM, He Xuehui, Vink Paul M, Wijnands Frank, Gorecka Monika, Klop Henri, Bauerschmidt Sussane, Garritsen Anja, Koenen Hans JPM, Joosten Irma, Boots Annemieke MH, Alkema Wynand
Format: Article
Language:English
Published: BMC 2012-03-01
Series:BMC Immunology
Subjects:
Signal transduction pathways
Gene expression profiling
T lymphocytes
Th1 and Th2 development
Online Access:http://www.biomedcentral.com/1471-2172/13/12

Internet

http://www.biomedcentral.com/1471-2172/13/12

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