Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia

Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia

Sepsis is a major cause of neonatal morbidity and mortality. The current paradigm suggests that neonatal susceptibility to infection is explained by an innate immune response that is functionally immature. Recent studies in adults have questioned a therapeutic role for IFNβ in sepsis; however, the r...

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Bibliographic Details
Main Authors: Sarah McKenna, Taylor Burey, Jeryl Sandoval, Leanna Nguyen, Odalis Castro, Suma Gudipati, Jazmin Gonzalez, Karim C. El Kasmi, Clyde J. Wright
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
neonate
endotoxemia
interferon beta
IRF3
STAT-1
NF-kappa B
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02210/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02210/full

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