Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.

Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.

The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we fou...

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Main Authors: Songbo Xie, Miao Chen, Bing Yan, Xianfei He, Xiwen Chen, Dengwen Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3981814?pdf=render
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spelling doaj-8f87e47bc79d4049b8cb76d5517fa9d82020-11-25T01:02:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9449610.1371/journal.pone.0094496Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.Songbo XieMiao ChenBing YanXianfei HeXiwen ChenDengwen LiThe innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders.http://europepmc.org/articles/PMC3981814?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Songbo Xie
Miao Chen
Bing Yan
Xianfei He
Xiwen Chen
Dengwen Li
spellingShingle Songbo Xie
Miao Chen
Bing Yan
Xianfei He
Xiwen Chen
Dengwen Li
Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
PLoS ONE
author_facet Songbo Xie
Miao Chen
Bing Yan
Xianfei He
Xiwen Chen
Dengwen Li
author_sort Songbo Xie
title Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
title_short Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
title_full Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
title_fullStr Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
title_full_unstemmed Identification of a role for the PI3K/AKT/mTOR signaling pathway in innate immune cells.
title_sort identification of a role for the pi3k/akt/mtor signaling pathway in innate immune cells.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2014-01-01
description The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated the role of the phosphatidylinositol 3 kinase (PI3K) signaling pathway in innate immune cells. By blocking this pathway with pharmacological inhibitors, we found that the production of proinflammatory cytokines was drastically suppressed in monocytes and macrophages. Further study revealed that the suppression was mainly related to the mammalian target of rapamycin (mTOR)/p70(S6K) signaling. In addition, we found that the PI3K pathway was involved in macrophage motility and neovascularization. Our data provide a rationale that inhibition of the PI3K signaling pathway could be an attractive approach for the management of inflammatory disorders.
url http://europepmc.org/articles/PMC3981814?pdf=render
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AT miaochen identificationofaroleforthepi3kaktmtorsignalingpathwayininnateimmunecells
AT bingyan identificationofaroleforthepi3kaktmtorsignalingpathwayininnateimmunecells
AT xianfeihe identificationofaroleforthepi3kaktmtorsignalingpathwayininnateimmunecells
AT xiwenchen identificationofaroleforthepi3kaktmtorsignalingpathwayininnateimmunecells
AT dengwenli identificationofaroleforthepi3kaktmtorsignalingpathwayininnateimmunecells
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