Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.

Bibliographic Details
Main Authors:	Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16929-8

id	doaj-8f93ea653e124b8e83b6b456aadd7c7e
record_format	Article
spelling	doaj-8f93ea653e124b8e83b6b456aadd7c7e2021-06-20T11:15:26ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16929-8Deconstructing sarcomeric structure–function relations in titin-BioID knock-in miceFranziska Rudolph0Claudia Fink1Judith Hüttemeister2Marieluise Kirchner3Michael H. Radke4Jacobo Lopez Carballo5Eva Wagner6Tobias Kohl7Stephan E. Lehnart8Philipp Mertins9Michael Gotthardt10Neuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationNeuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationNeuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationProteomics Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationNeuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationNeuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationHeart Research Center Göttingen, University Medical Center GöttingenHeart Research Center Göttingen, University Medical Center GöttingenHeart Research Center Göttingen, University Medical Center GöttingenProteomics Platform, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationNeuromuscular and Cardiovascular Cell Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz AssociationTitin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.https://doi.org/10.1038/s41467-020-16929-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Franziska Rudolph Claudia Fink Judith Hüttemeister Marieluise Kirchner Michael H. Radke Jacobo Lopez Carballo Eva Wagner Tobias Kohl Stephan E. Lehnart Philipp Mertins Michael Gotthardt
spellingShingle	Franziska Rudolph Claudia Fink Judith Hüttemeister Marieluise Kirchner Michael H. Radke Jacobo Lopez Carballo Eva Wagner Tobias Kohl Stephan E. Lehnart Philipp Mertins Michael Gotthardt Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice Nature Communications
author_facet	Franziska Rudolph Claudia Fink Judith Hüttemeister Marieluise Kirchner Michael H. Radke Jacobo Lopez Carballo Eva Wagner Tobias Kohl Stephan E. Lehnart Philipp Mertins Michael Gotthardt
author_sort	Franziska Rudolph
title	Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
title_short	Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
title_full	Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
title_fullStr	Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
title_full_unstemmed	Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice
title_sort	deconstructing sarcomeric structure–function relations in titin-bioid knock-in mice
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
url	https://doi.org/10.1038/s41467-020-16929-8
work_keys_str_mv	AT franziskarudolph deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT claudiafink deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT judithhuttemeister deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT marieluisekirchner deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT michaelhradke deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT jacobolopezcarballo deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT evawagner deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT tobiaskohl deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT stephanelehnart deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT philippmertins deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice AT michaelgotthardt deconstructingsarcomericstructurefunctionrelationsintitinbioidknockinmice
_version_	1721370239161073664

Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

Similar Items