Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis

Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis

SCP1 as a nuclear transcriptional regulator acts globally to silence neuronal genes and to affect the dephosphorylation of RNA Pol ll. However, we report the first finding and description of SCP1 as a plasma membrane-localized protein in various cancer cells using EGFP- or other epitope-fused SCP1....

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Bibliographic Details
Main Authors: Peng Liao, Weichao Wang, Yu Li, Rui Wang, Jiali Jin, Weijuan Pang, Yunfei Chen, Mingyue Shen, Xinbo Wang, Dongyang Jiang, Jinjiang Pang, Mingyao Liu, Xia Lin, Xin-Hua Feng, Ping Wang, Xin Ge
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-04-01
Series:eLife
Subjects:
human cancer cell lines
angiogenesis
tumorigenesis
Online Access:https://elifesciences.org/articles/22058

Internet

https://elifesciences.org/articles/22058

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