Cell-type specific expression of a dominant negative PKA mutation in mice.

Cell-type specific expression of a dominant negative PKA mutation in mice.

We employed the Cre recombinase/loxP system to create a mouse line in which PKA activity can be inhibited in any cell-type that expresses Cre recombinase. The mouse line carries a mutant Prkar1a allele encoding a glycine to aspartate substitution at position 324 in the carboxy-terminal cAMP-binding...

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Bibliographic Details
Main Authors: Brandon S Willis, Colleen M Niswender, Thomas Su, Paul S Amieux, G Stanley McKnight
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3075275?pdf=render

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http://europepmc.org/articles/PMC3075275?pdf=render

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