Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions

Fas signaling-mediated TH9 cell differentiation favors bowel inflammation and antitumor functions

Fas signalling induces apoptosis of activated T cells to maintain immune homeostasis. Here the authors show that Fas also induces PKC-β activation to promote NF-κB-mediated TH9 cell differentiation, while p38 activation by PKC-β antagonizes this effect, thereby supporting a synergy between p38 inhib...

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Bibliographic Details
Main Authors: Yingying Shen, Zhengbo Song, Xinliang Lu, Zeyu Ma, Chaojie Lu, Bei Zhang, Yinghu Chen, Meng Duan, Lionel Apetoh, Xu Li, Jufeng Guo, Ying Miao, Gensheng Zhang, Diya Yang, Zhijian Cai, Jianli Wang
Format: Article
Language:English
Published: Nature Publishing Group 2019-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10889-4

Internet

https://doi.org/10.1038/s41467-019-10889-4

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