The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents

The Natural Compound Climacostol as a Prodrug Strategy Based on pH Activation for Efficient Delivery of Cytotoxic Small Agents

We synthesized and characterized MOMO as a new small molecule analog of the cytotoxic natural product climacostol efficiently activated in mild extracellular acidosis. The synthesis of MOMO had a key step in the Wittig olefination for the construction of the carbon-carbon double bond in the alkenyl...

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Bibliographic Details
Main Authors: Elisabetta Catalani, Federico Buonanno, Gabriele Lupidi, Silvia Bongiorni, Riccardo Belardi, Silvia Zecchini, Matteo Giovarelli, Marco Coazzoli, Clara De Palma, Cristiana Perrotta, Emilio Clementi, Giorgio Prantera, Enrico Marcantoni, Claudio Ortenzi, Anna Maria Fausto, Simona Picchietti, Davide Cervia
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Chemistry
Subjects:
small natural agents
ciliated protists
Wittig olefination
pH-activation
cytotoxic compound
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00463/full

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https://www.frontiersin.org/article/10.3389/fchem.2019.00463/full

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