Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy

Abstract Background The trans-neuronal propagation of tau has been implicated in the progression of tau-mediated neurodegeneration. There is critical knowledge gap in understanding how tau is released and transmitted, and how that is dysregulated in diseases. Previously, we reported that lysine acet...

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Bibliographic Details
Main Authors: Xu Chen, Yaqiao Li, Chao Wang, Yinyan Tang, Sue-Ann Mok, Richard M. Tsai, Julio C. Rojas, Anna Karydas, Bruce L. Miller, Adam L. Boxer, Jason E. Gestwicki, Michelle Arkin, Ana Maria Cuervo, Li Gan
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Molecular Neurodegeneration
Subjects:
Tauopathy
Tau secretion
Tau spreading
Autophagy-lysosomal pathway
p300/CBP
Online Access:https://doi.org/10.1186/s13024-019-0354-0

Internet

https://doi.org/10.1186/s13024-019-0354-0

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