RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.

RIG-I-like receptor activation by dengue virus drives follicular T helper cell formation and antibody production.

Follicular T helper cells (TFH) are fundamental in orchestrating effective antibody-mediated responses critical for immunity against viral infections and effective vaccines. However, it is unclear how virus infection leads to TFH induction. We here show that dengue virus (DENV) infection of human de...

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Bibliographic Details
Main Authors: Joris K Sprokholt, Tanja M Kaptein, John L van Hamme, Ronald J Overmars, Sonja I Gringhuis, Teunis B H Geijtenbeek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-11-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5724900?pdf=render

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http://europepmc.org/articles/PMC5724900?pdf=render

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