Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination

Deletion of CD38 Suppresses Glial Activation and Neuroinflammation in a Mouse Model of Demyelination

CD38 is an enzyme that catalyzes the synthesis of cyclic adenosine diphosphate-ribose from nicotinamide adenine dinucleotide (NAD+). We recently reported that this molecule regulates the maturation and differentiation of glial cells such as astrocytes and oligodendrocytes (OLs) in the developing bra...

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Bibliographic Details
Main Authors: Jureepon Roboon, Tsuyoshi Hattori, Hiroshi Ishii, Mika Takarada-Iemata, Thuong Manh Le, Yoshitake Shiraishi, Noriyuki Ozaki, Yasuhiko Yamamoto, Akira Sugawara, Hiroshi Okamoto, Haruhiro Higashida, Yasuko Kitao, Osamu Hori
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
demyelination
gliosis
cuprizone
neuroinflammation
NAD+
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00258/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00258/full

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