Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells

Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells

Abstract The PI3K/AKT/mTOR signaling pathway is constitutively active in PTEN-deficient cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the efficacy of targeted therapies is often limited due to drug resistance. The relevant signaling pathways in PTEN-deficient...

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Bibliographic Details
Main Authors: Jian Wang, Xiaoye Lv, Xiutian Guo, Yanbo Dong, Peipei Peng, Fang Huang, Peng Wang, Haoqian Zhang, Jianguang Zhou, Youliang Wang, Bo Wei, Zeng-Fu Shang, Shanhu Li
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Oncogenesis
Online Access:https://doi.org/10.1038/s41389-020-00292-w

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https://doi.org/10.1038/s41389-020-00292-w

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