p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.

p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.

Mad2, a key component of the spindle checkpoint, is closely associated with chromosomal instability and poor prognosis in cancer. p31comet is a Mad2-interacting protein that serves as a spindle checkpoint silencer at mitosis. In this study, we showed that p31comet-induced apoptosis and senescence oc...

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Bibliographic Details
Main Authors: Hyun-Jin Shin, Eun-Ran Park, Sun-Hee Yun, Su-Hyeon Kim, Won-Hee Jung, Seon Rang Woo, Hyun-Yoo Joo, Su Hwa Jang, Hee Yong Chung, Sung Hee Hong, Myung-Haing Cho, Joong-Jean Park, Miyong Yun, Kee-Ho Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4636321?pdf=render

Internet

http://europepmc.org/articles/PMC4636321?pdf=render

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