Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent

Structure-activity relationships study of isothiocyanates for H2S releasing properties: 3-Pyridyl-isothiocyanate as a new promising cardioprotective agent

Introduction: The gasotransmitter hydrogen sulphide (H2S), an endogenous ubiquitous signalling molecule, is known for its beneficial effects on different mammalian systems. H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury. Methods: A library of forty-five i...

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Bibliographic Details
Main Authors: Valentina Citi, Angela Corvino, Ferdinando Fiorino, Francesco Frecentese, Elisa Magli, Elisa Perissutti, Vincenzo Santagada, Simone Brogi, Lorenzo Flori, Era Gorica, Lara Testai, Alma Martelli, Vincenzo Calderone, Giuseppe Caliendo, Beatrice Severino
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Journal of Advanced Research
Subjects:
Hydrogen sulfide
H2S releasing compounds
Isothiocyanates
In silico prediction
Cardioprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123220300412

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http://www.sciencedirect.com/science/article/pii/S2090123220300412

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