Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis

Mouse Genetic Models Reveal Surprising Functions of IkB Kinase Alpha in Skin Development and Skin Carcinogenesis

Gene knockout studies unexpectedly reveal a pivotal role for IkB kinase alpha (IKKa) in mouse embryonic skin development. Skin carcinogenesis experiments show that Ikka heterozygous mice are highly susceptible to chemical carcinogen or ultraviolet B light (UVB) induced benign and malignant skin tumo...

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Bibliographic Details
Main Authors: Yinling Hu, Xiaojun Xia, Eunmi Park, Susan M. Fischer
Format: Article
Language:English
Published: MDPI AG 2013-02-01
Series:Cancers
Subjects:
skin carcinogenesis
skin development
IKKalpha (IKKa)
Online Access:http://www.mdpi.com/2072-6694/5/1/170

Internet

http://www.mdpi.com/2072-6694/5/1/170

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