Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model

Anti-Tumor Efficiency of Perillylalcohol/β-Cyclodextrin Inclusion Complexes in a Sarcoma S180-Induced Mice Model

The low solubility and high volatility of perillyl alcohol (POH) compromise its bioavailability and potential use as chemotherapeutic drug. In this work, we have evaluated the anticancer activity of POH complexed with β-cyclodextrin (β-CD) using three complexation approaches. Molecular docking sugge...

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Bibliographic Details
Main Authors: Allan A. Rezende, Rafael S. Santos, Luciana N. Andrade, Ricardo G. Amaral, Matheus M. Pereira, Cristiane Bani, Mo Chen, Ronny Priefer, Classius F. da Silva, Ricardo L. C. de Albuquerque Júnior, Eliana B. Souto, Patrícia Severino
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
perillyl alcohol
cyclodextrin
inclusion complex
anti-cancer
sarcoma
Online Access:https://www.mdpi.com/1999-4923/13/2/245

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https://www.mdpi.com/1999-4923/13/2/245

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