Chidamide Enhances the Cytotoxicity of Cytarabine and Sorafenib in Acute Myeloid Leukemia Cells by Modulating H3K9me3 and Autophagy Levels

Chidamide Enhances the Cytotoxicity of Cytarabine and Sorafenib in Acute Myeloid Leukemia Cells by Modulating H3K9me3 and Autophagy Levels

Previous studies showed that chidamide enhances the cytotoxicity of drugs in acute myeloid leukemia (AML) cells. Therefore, we examined whether chidamide enhanced the cytotoxicity of drugs in AML cells by affecting H3K9me3 and autophagy levels. AML cells (THP-1 and MV4-11 cells) were treated with ch...

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Bibliographic Details
Main Authors: He Huang, Yang Wenbing, Aishu Dong, Zhewei He, Rongxing Yao, Wenjian Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
chidamide
H3K9me3
autophagy
SIRT1
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01276/full

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https://www.frontiersin.org/article/10.3389/fonc.2019.01276/full

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