Effectiveness and safety of high dose clopidogrel plus aspirin in ischemic stroke patients with the single CYP2C19 loss-of-function allele: a randomized trial

Effectiveness and safety of high dose clopidogrel plus aspirin in ischemic stroke patients with the single CYP2C19 loss-of-function allele: a randomized trial

Abstract Background Dual antiplatelet aggregation therapy leads to better outcomes in patients with carotid artery stenosis, intracranial artery stenosis, minor strokes, or transient ischaemic attacks. However, carriers of the CYP2C19 loss-of-function allele may not experience the desired effects. W...

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Bibliographic Details
Main Authors: Hongliang Wu, Huiqun Song, Lianwei Dou, Bo Gao, Yan Pan, Mei Dong, Qi Chen, Jiazhen Li, Lixiang Song, Chuanyu Liu, Bing Li, Wenzheng Chu
Format: Article
Language:English
Published: BMC 2020-10-01
Series:BMC Neurology
Subjects:
Ischaemic stroke
Intracranial stenosis
Carotid stenosis
CYP2C19
Clopidogrel
Dual antiplatelet aggregation therapy
Online Access:http://link.springer.com/article/10.1186/s12883-020-01974-z

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http://link.springer.com/article/10.1186/s12883-020-01974-z

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