Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

The title compounds, C22H29NO2 (3) and C22H29NO2 (4) [systematic names: (1S*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol and (1R*,2R*)-7-methoxy-2-methyl-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol, are diastereomers with the relative configuration...

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Bibliographic Details
Main Authors: Bastian Tewes, Bastian Frehland, Roland Fröhlich, Bernhard Wünsch
Format: Article
Language:English
Published: International Union of Crystallography 2016-05-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
crystal structure
NMDA receptor antagonists
GluN2B antagonists
ifenprodil analogs
tetrahydro-3-benzazepines
relative configuration
conformational restriction
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989016005843

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http://scripts.iucr.org/cgi-bin/paper?S2056989016005843

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