Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets

Statistical assessment and visualization of synergies for large-scale sparse drug combination datasets

Abstract Background Drug combinations have the potential to improve efficacy while limiting toxicity. To robustly identify synergistic combinations, high-throughput screens using full dose-response surface are desirable but require an impractical number of data points. Screening of a sparse number o...

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Bibliographic Details
Main Authors: Arnaud Amzallag, Sridhar Ramaswamy, Cyril H. Benes
Format: Article
Language:English
Published: BMC 2019-02-01
Series:BMC Bioinformatics
Subjects:
Drug combination
Synergy
High-throughput screen
Cancer therapy
Cancer cell lines
Melanoma
Online Access:http://link.springer.com/article/10.1186/s12859-019-2642-7

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http://link.springer.com/article/10.1186/s12859-019-2642-7

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