Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

Apelin-13/APJ system attenuates early brain injury via suppression of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation and oxidative stress in a AMPK-dependent manner after subarachnoid hemorrhage in rats

Abstract Background Neuroinflammation and oxidative stress play important roles in early brain injury following subarachnoid hemorrhage (SAH). This study is the first to show that activation of apelin receptor (APJ) by apelin-13 could reduce endoplasmic reticulum (ER)-stress-associated inflammation...

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Bibliographic Details
Main Authors: Weilin Xu, Tao Li, Liansheng Gao, Jingwei Zheng, Jun Yan, Jianmin Zhang, Anwen Shao
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Early brain injury
SAH
Neuroinflammation
Oxidative stress
Apelin-13
APJ
Online Access:https://doi.org/10.1186/s12974-019-1620-3

Internet

https://doi.org/10.1186/s12974-019-1620-3

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