Local Stabilization of Hypoxia-Inducible Factor-1α Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation

Local Stabilization of Hypoxia-Inducible Factor-1α Controls Intestinal Inflammation via Enhanced Gut Barrier Function and Immune Regulation

Intestinal epithelial cells are adapted in mucosal hypoxia and hypoxia-inducible factors in these cells can fortify barrier integrity to support mucosal tissue healing. Here we investigated whether hypoxia-related pathways could be proposed as potential therapeutic targets for inflammatory bowel dis...

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Bibliographic Details
Main Authors: Young-In Kim, Eun-Je Yi, Young-Dae Kim, A Reum Lee, Jiwoung Chung, Hae Chan Ha, Joong Myung Cho, Seong-Ryeol Kim, Hyun-Jeong Ko, Jae-Hee Cheon, Yong Rae Hong, Sun-Young Chang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
gut barrier
hypoxia-inducible factor
prolyl hydroxylase inhibitor
immune regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.609689/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.609689/full

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