Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

Protective Effects of the Soluble Epoxide Hydrolase Inhibitor 1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea in a Rat Model of Permanent Middle Cerebral Artery Occlusion

Acute ischemic stroke is a serious disease that endangers human health. In our efforts to develop an effective therapy, we previously showed that the potent, highly selective inhibitor of soluble epoxide hydrolase called 1-trifuoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU) protects the...

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Bibliographic Details
Main Authors: Linlei Zhang, Shasha Xu, Xiaoxiao Wu, Farah Mohamed Muse, Jiaou Chen, Yungang Cao, Jueyue Yan, Zicheng Cheng, Xingyang Yi, Zhao Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
TPPU
blood brain barrier
cerebral ischemia
apoptosis
tight junction
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00182/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00182/full

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