Investigating the Glycating Effects of Glucose, Glyoxal and Methylglyoxal on Human Sperm

Abstract Glycation is the non-enzymatic reaction between reducing sugars, such as glucose, and proteins, lipids or nucleic acids, producing Advanced Glycation End (AGE) products. AGEs, produced during natural senescence as well as through lifestyle factors such as diet and smoking, are key pathogeni...

Full description

Bibliographic Details
Main Authors: Clare Nevin, Lauren McNeil, Nessar Ahmed, Chris Murgatroyd, Daniel Brison, Michael Carroll
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-27108-7