Estradiol Alleviates Intervertebral Disc Degeneration through Modulating the Antioxidant Enzymes and Inhibiting Autophagy in the Model of Menopause Rats

Objective. To investigate the effects of menopause on redox balance in the intervertebral disc and to examine whether oxidative stress and autophagy were associated with disc degeneration in menopause rats. Methods. Thirty female Sprague-Dawley rats were randomly divided into three groups (sham, ova...

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Bibliographic Details
Main Authors: Lin-Yu Jin, Zhen-Dong Lv, Kun Wang, Lie Qian, Xiao-Xing Song, Xin-Feng Li, Hong-Xing Shen
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2018/7890291