Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin/IGF1R signaling and activation of AKT/mTOR.

Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin/IGF1R signaling and activation of AKT/mTOR.

Obesity and diabetes are associated with increased breast cancer risk and worse disease progression once cancer is diagnosed; however, the exact etiology behind these observations remains to be fully elucidated. Due to the global obesity/diabetes pandemic, it is imperative to understand how these di...

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Bibliographic Details
Main Authors: Rebecca Lopez, Arunkumar Arumugam, Riya Joseph, Kanika Monga, Thiyagarajan Boopalan, Pamela Agullo, Christina Gutierrez, Sushmita Nandy, Ramadevi Subramani, Jose Manuel de la Rosa, Rajkumar Lakshmanaswamy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3832533?pdf=render

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http://europepmc.org/articles/PMC3832533?pdf=render

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