The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse

The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse

Alcoholism initiates with episodes of excessive alcohol drinking, known as binge drinking, which is one form of excessive drinking (NIAAA Newsletter, 2004) that is related to impulsivity and anxiety (Ducci et al., 2007; Edenberg et al., 2004) and is also predictive of smoking status. The predisposit...

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Bibliographic Details
Main Authors: Irina Balan, Kaitlin T. Warnock, Adam Puche, Marjorie C. Gondre-Lewis, Harry June, Laure Aurelian
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:Brain Sciences
Subjects:
TLR4 signal
PKA/CREB
CRF/TH
GABAA α2
HSV siRNA vectors
alcohol/nicotine abuse
Online Access:http://www.mdpi.com/2076-3425/8/4/72

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http://www.mdpi.com/2076-3425/8/4/72

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