A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

A Novel Tetramethylpyrazine Derivative Prophylactically Protects against Glutamate-Induced Excitotoxicity in Primary Neurons through the Blockage of N-Methyl-D-aspartate Receptor

The over-activation of NMDA receptor via the excessive glutamate is believed to one of the most causal factors associated with Alzheimer’s disease (AD), a progressive neurodegenerative brain disorder. Molecules that could protect against glutamate-induced neurotoxicity may hold therapeutic values fo...

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Bibliographic Details
Main Authors: Shengquan Hu, Huihui Hu, Shinghung Mak, Guozhen Cui, Mingyuen Lee, Luchen Shan, Yuqiang Wang, Huangquan Lin, Zaijun Zhang, Yifan Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
tetramethylpyrazine derivative
NMDA receptor
neuroprotection
oxidative stress
GSK3β
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00073/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00073/full

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