Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

Yap1 plays a protective role in suppressing free fatty acid-induced apoptosis and promoting beta-cell survival

ABSTRACT Mammalian pancreatic β-cells play a pivotal role in development and glucose homeostasis through the production and secretion of insulin. Functional failure or decrease in β-cell number leads to type 2 diabetes (T2D). Despite the physiological importance of β-cells, the viability of β-cells...

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Bibliographic Details
Main Authors: Yaoting Deng, Yurika Matsui, Wenfei Pan, Qiu Li, Zhi-Chun Lai
Format: Article
Language:English
Published: SpringerOpen 2016-03-01
Series:Protein & Cell
Subjects:
β-cell
CTGF
F-actin
free fatty acid
Hippo signaling
Yap1
Online Access:http://link.springer.com/article/10.1007/s13238-016-0258-5

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http://link.springer.com/article/10.1007/s13238-016-0258-5

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