Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem ce...

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Bibliographic Details
Main Authors: Bing Zhao, Ying Chen, Ning Jiang, Li Yang, Shenfei Sun, Yan Zhang, Zengqi Wen, Lorraine Ray, Han Liu, Guoli Hou, Xinhua Lin
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09060-w

Internet

https://doi.org/10.1038/s41467-019-09060-w

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