Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem ce...

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Main Authors:	Bing Zhao, Ying Chen, Ning Jiang, Li Yang, Shenfei Sun, Yan Zhang, Zengqi Wen, Lorraine Ray, Han Liu, Guoli Hou, Xinhua Lin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09060-w

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spelling	doaj-8ff28e5c8ddf474a853435819bbaaa662021-05-11T11:51:19ZengNature Publishing GroupNature Communications2041-17232019-03-0110111210.1038/s41467-019-09060-wZnhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporationBing Zhao0Ying Chen1Ning Jiang2Li Yang3Shenfei Sun4Yan Zhang5Zengqi Wen6Lorraine Ray7Han Liu8Guoli Hou9Xinhua Lin10State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityDivision of Developmental Biology, Cincinnati Children’s Hospital Medical CenterNational Laboratory of Biomacromolecules, CAS Center for Excellence in Institute of Biophysics, Chinese Academy of SciencesDivision of Developmental Biology, Cincinnati Children’s Hospital Medical CenterState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan UniversityLgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem cell fate.https://doi.org/10.1038/s41467-019-09060-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Bing Zhao Ying Chen Ning Jiang Li Yang Shenfei Sun Yan Zhang Zengqi Wen Lorraine Ray Han Liu Guoli Hou Xinhua Lin
spellingShingle	Bing Zhao Ying Chen Ning Jiang Li Yang Shenfei Sun Yan Zhang Zengqi Wen Lorraine Ray Han Liu Guoli Hou Xinhua Lin Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation Nature Communications
author_facet	Bing Zhao Ying Chen Ning Jiang Li Yang Shenfei Sun Yan Zhang Zengqi Wen Lorraine Ray Han Liu Guoli Hou Xinhua Lin
author_sort	Bing Zhao
title	Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_short	Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_full	Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_fullStr	Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_full_unstemmed	Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation
title_sort	znhit1 controls intestinal stem cell maintenance by regulating h2a.z incorporation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-03-01
description	Lgr5+ stem cells in intestinal crypts are critical for gut epithelium homeostasis. Here, the authors show that Znht1 critically regulates intestinal homeostasis by promoting interaction between histone variant H2A.Z and its chaperone YL1 to incorporate H2A.Z into genes involved in intestinal stem cell fate.
url	https://doi.org/10.1038/s41467-019-09060-w
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Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation

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