A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle

Chordoid glioma is a rare low-grade brain tumor that originates from the anterior wall of the third ventricle where surgical resection is challenging; the clinical outcome of patients after subtotal resection or disease recurrence is poor. Here the authors identify a recurrent missense mutation in P...

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Bibliographic Details
Main Authors: Benjamin Goode, Gourish Mondal, Michael Hyun, Diego Garrido Ruiz, Yu-Hsiu Lin, Jessica Van Ziffle, Nancy M. Joseph, Courtney Onodera, Eric Talevich, James P. Grenert, Iman H. Hewedi, Matija Snuderl, Daniel J. Brat, Bette K. Kleinschmidt-DeMasters, Fausto J. Rodriguez, David N. Louis, William H. Yong, M. Beatriz Lopes, Marc K. Rosenblum, Nicholas Butowski, Tarik Tihan, Andrew W. Bollen, Joanna J. Phillips, Arun P. Wiita, Iwei Yeh, Matthew P. Jacobson, Boris C. Bastian, Arie Perry, David A. Solomon
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-02826-8

Internet

https://doi.org/10.1038/s41467-018-02826-8

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