Cigarette smoke affects keratinocytes SRB1 expression and localization via H2O2 production and HNE protein adducts formation.

Scavenger Receptor B1 (SR-B1), also known as HDL receptor, is involved in cellular cholesterol uptake. Stratum corneum (SC), the outermost layer of the skin, is composed of more than 25% cholesterol. Several reports support the view that alteration of SC lipid composition may be the cause of impaire...

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Main Authors: Claudia Sticozzi, Giuseppe Belmonte, Alessandra Pecorelli, Beatrice Arezzini, Concetta Gardi, Emanuela Maioli, Clelia Miracco, Marzia Toscano, Henry Jay Forman, Giuseppe Valacchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22442701/pdf/?tool=EBI