Deprivation of the Periplasmic Chaperone SurA Reduces Virulence and Restores Antibiotic Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa

Deprivation of the Periplasmic Chaperone SurA Reduces Virulence and Restores Antibiotic Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa

Pseudomonas aeruginosa is one of the main causative agents of nosocomial infections and the spread of multidrug-resistant strains is rising. Therefore, novel strategies for therapy are urgently required. The outer membrane composition of Gram-negative pathogens and especially of Pa restricts the eff...

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Bibliographic Details
Main Authors: Kristina Klein, Michael S. Sonnabend, Lisa Frank, Karolin Leibiger, Mirita Franz-Wachtel, Boris Macek, Thomas Trunk, Jack C. Leo, Ingo B. Autenrieth, Monika Schütz, Erwin Bohn
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
SurA
Pseudomonas aeruginosa
virulence
multidrug resistance
antibiotics
outer membrane protein biogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00100/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00100/full

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