Deprivation of the Periplasmic Chaperone SurA Reduces Virulence and Restores Antibiotic Susceptibility of Multidrug-Resistant Pseudomonas aeruginosa
Pseudomonas aeruginosa is one of the main causative agents of nosocomial infections and the spread of multidrug-resistant strains is rising. Therefore, novel strategies for therapy are urgently required. The outer membrane composition of Gram-negative pathogens and especially of Pa restricts the eff...
Main Authors: | Kristina Klein, Michael S. Sonnabend, Lisa Frank, Karolin Leibiger, Mirita Franz-Wachtel, Boris Macek, Thomas Trunk, Jack C. Leo, Ingo B. Autenrieth, Monika Schütz, Erwin Bohn |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2019-02-01
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Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2019.00100/full |
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