Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

Validation of computational determination of microsatellite status using whole exome sequencing data from colorectal cancer patients

Abstract Background Microsatellite instability (MSI), resulting from a defective mismatch repair system, occurs in approximately 15% of sporadic colorectal cancers (CRC). Since MSI is associated with a poor response to 5-fluorouracile based chemotherapy and is a positive predictive marker of immunot...

Full description

Bibliographic Details
Main Authors: Amanda Frydendahl Boll Johansen, Christine Gaasdal Kassentoft, Michael Knudsen, Maria Bach Laursen, Anders Husted Madsen, Lene Hjerrild Iversen, Kåre Gotschalck Sunesen, Mads Heilskov Rasmussen, Claus Lindbjerg Andersen
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Cancer
Subjects:
MSIsensor
Colorectal cancer
DNA mismatch repair deficiency
Microsatellite instability
MSI
MSS
Online Access:http://link.springer.com/article/10.1186/s12885-019-6227-7

Internet

http://link.springer.com/article/10.1186/s12885-019-6227-7

Similar Items