The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism

The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism

N-acetyltransferase 2 (NAT2) catalyzes the acetylation of isoniazid to N-acetylisoniazid. NAT2 polymorphism explains 88% of isoniazid clearance variability in adults. We examined the effects of clinical and genetic factors on Michaelis-Menten reaction kinetic constants of maximum velocity (Vmax) and...

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Bibliographic Details
Main Authors: Zoe Rogers, Hiwot Hiruy, Jotam G. Pasipanodya, Chris Mbowane, John Adamson, Lihle Ngotho, Farina Karim, Prakash Jeena, William Bishai, Tawanda Gumbo
Format: Article
Language:English
Published: Elsevier 2016-09-01
Series:EBioMedicine
Subjects:
NAT2 reaction kinetics
Isoniazid concentration
Maturation
NAT2 genotype
Artificial intelligence
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396416303413

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http://www.sciencedirect.com/science/article/pii/S2352396416303413

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